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fipronil side effects

In a study to determine the side effects of Fipronil, rats were given the drug for 52 weeks, and they developed increased liver mass, thyroid hormonal changes, and kidney effects. In a rat study on fipronil exposure, long-term exposure to fipronil caused an increase in seizures and death among the test animal. It is not intended as a substitute for professional advice of any kind. Fipronil has the molecular formula of C12H4Cl2F6N4OS. Other symptoms include twitching, nodding, aggression, sweating, nausea, lack of appetite, vomiting, headache, abdominal pain, dizziness, agitation, and weakness. Stomach pain or heartburn. Although this sensation should subside, persistent irritation warrants a vet check. ).Some health conditions may make you more susceptible to the side-effects of the drug. Generic Name: aspirin / butalbital / caffeine. not recommended for use in debilitated or geriatric animals. However, many people have no side effects or only have minor side effects. Fipronil was also found to be toxic to some birds, but not ducks, and to honey bees. Fipronil is a phenylpryazole insecticide that is used to control insects, such as ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, and weevils. Some of the side … Skin issues â€” As mentioned earlier, fipronil can cause irritation to your dog’s skin. Fipronil side effects. Regards Dr Callum Turner DVM. Prolonged or repeated exposure to the chemical may bring damage to the body organs exposed. Fipronil works by interrupting the normal functioning of the central nervous system in insects when they eat it or come in contact with it. In addition, it is essential to use personal protective equipment when working with the insecticide. In insects and vertebrates, severe poisoning by fipronil is manifested by excitation, paralysis and death. Side effects are uncommon, but may include skin irritation at the application site. They could also breathe these chemicals in. Fipronil inhibits the opening of gamma aminobutyric acid (GABA)-mediated chloride channels, and therefore the excitatory effect of sodium is unchecked. These are not all of the side effects that may occur. Skin problems – As stated earlier, fipronil can cause irritation to your dog’s skin. While generally safe and effective when prescribed by a veterinarian, fipronil and methoprene can cause side effects in some animals. Use caution when administering this drug to aging or debilitated pets. Fipronil and methoprene should not be used in animals with known hypersensitivity or allergy to the drug. Moreover, it was found to reduce thyroid hormone levels among rats. Wednesday, November 29, 2017 by Michelle Simmons, http://www.naturalpedia.com/fipronil-toxicity-side-effects-diseases-and-environmental-impacts.html. Some of the dosage forms listed on this page may not apply to the brand name Fiorinal. You might even apply these chemicals directly to their fur to treat fleas and ticks. Precautions and Side Effects While generally safe and effective when prescribed by a veterinarian, fipronil can cause side effects in some animals. "Product Information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Feeling sleepy. Eye protection is not normally required, but it is advised to refrain from touching the eyes while handling the product. According to various consumer sites, potential side effects of Frontline for Cats include: Temporary redness or skin irritation Do not use this product on pets less than 8 weeks old, geriatric pets, or sick/weak pets. Fipronil should not be used in animals with known hypersensitivity or allergy to the drug. If you notice any of the following side effects take your pet to the vet immediately: Swelling particularly of the face, lips and tongue Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Fipronil is … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. For example, they could run around or lie down in treated areas and then lick these chemicals off their fur when groomingthemselves. These body systems include the nervous, muscular, ocular, integumentary, reproductive, respiratory, and digestive systems. This drug is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian. Fipronil is practically non-toxic to mallard ducks with no documented acute, sub-acute, or chronic effects. The NOAEL for parental systemic toxicity was 3 ppm, equal to 0.25 mg/kg bw per day, and the NOAEL for reproductive toxicity was 30 ppm, equal to 2.5 mg/kg bw per day. Possible side effects (S)-methoprene alone is well tolerated by dogs and cats, with a low toxicity and high safety margin. It also lowered the survival rate and slowed down the development among offspring. Fipronil is an insecticide that belongs to the group of phenylpryazole chemicals. Frontline Side Effects Since the active ingredient fipronil works as a pesticide, it's important to avoid using the treatment along with other pesticides. It is used to eliminate ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects. vitamins, herbal supplements, etc. "Product Information. The most common symptoms of fipronil poisioning include ataxia or uncoordinated movements, hyper-reactivity or exaggerated reaction to stimuli, tremor or uncontrolled trembling or shaking movements, cramps or sudden, involuntary contractions of muscles, convulsions, abnormal gait, and seizure. Another way to avoid skin contact is to wear waterproof gloves. Fipronil should not be used in animals with known hypersensitivity or allergy to the drug. Call your doctor or get medical Its effects included less mating, decreased fertility, smaller litter size, and higher loss of pregnancy. Fipronil can cause many side effects in humans. This inflammation can surpass basic itching as … Side Effects and Drug Reactions. Precautions and Side Effects While generally safe and effective when prescribed by a veterinarian, fipronil can cause side effects in some animals. While generally safe and effective when prescribed by a veterinarian, fipronil can cause side effects in some animals. Fipronil may also cause local dermatitis or skin irritation with pruritus or itching, and erythema or red skin. 1. There are many concerns about possible side effects, the most common being skin reactions like hair loss, itching, and redness, and neurological issues like uncoordinated movement and lethargy. Signs of an allergic reaction, like rash. Signs and symptoms from a brief exposure to fipronil generally improve and clear up without treatment. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. While the common side effect to Frontline is skin responses, its active component, fipronil, lists other prospective issues when used on dogs. Applies to aspirin / butalbital / caffeine: oral capsule, oral tablet. Fipronil may irritate the skin, eyes, gastrointestinal tract, and respiratory tract. aspirin, acetaminophen, tramadol, ibuprofen, Tylenol, naproxen, diclofenac, oxycodone, celecoxib, sumatriptan. It can also be toxic to the nervous system, particularly if ingested. This insecticide is most commonly used on rice crops and to treat rice seeds. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Before using Fipronil, inform your doctor about your current list of medications, over the counter products (e.g. Side Effect for Humans Fipronil is a suspected human carcinogen and endocrine disruptor. Side effects experienced by dogs and cats after treatment with products containing (S)-methoprene can generally be attributed to the other active or inert ingredients. When individuals have eaten fipronil, reported health effects included sweating, nausea, vomiting, headache, stomach pain, dizziness, weakness, and seizures. Interestingly, finding information on the side effects for Frontline Plus and the rest of the brand is somewhat difficult, as the company does not appear to publicly list side effects. Fipronil is used topically to treat flea, tick, and chewing lice infestations. Fipronil can also disrupt thyroid function and causes thyroid cancer in rats at doses of 300 parts per million. A review of side effects reported in Australia between 1996 and 2003 found that the most common side effect of using fipronil for dogs was skin irritation or hair loss at the application site. You may also report side effects at https://www.fda.gov/medwatch. Fipronil stays in the oil glands on the cat's skin and is generally effective for the next 30 days before reapplication is necessary. There are several body systems that the herbicide ethofumesate can adversely affect. It may also cause irritation on the eyes. I would try using a different product like Frontline (fipronil) to see if there are any negative effects from use. For its environmental side effects, it has been found to be extremely toxic to fish, aquatic invertebrates like shrimp and water fleas, and to the aquatic environment. Fiorinal (ASA/butalbital/caffeine)" Actavis (formerly Abrika Pharmaceuticals LLP), Sunrise, FL. Major Pharmaceuticals Inc, Livonia, MI. Fipronil should not be used in animals with known hypersensitivity or allergy to the drug. Moreover, it is an ingredient in some tick and lice control medications for pets. Upset stomach. ), allergies, pre-existing diseases, and current health conditions (e.g. Fipronil may result in these side effects: Drooling; Irritation at application site; Fipronil does not appear to react with any other drugs. Fipronil in the food chain is closely monitored and no such side-effects have been reported from household use. To avoid skin contact, it is important to wear full-length work clothes. Small animals may show such symptoms as irritation, lethargy, uncoordinated movement and convulsions from overexposure to fipronil. “Frontline Top Spot” is not recommended for use in debilitated or geriatric animals. Aspirin/Butalbital/Caffeine (aspirin / butalbital / caffeine (acetylsalicylic acid/butalbital/caffeine))." Truth Publishing assumes no responsibility for the use or misuse of this material. Fipronil is used for insecticide and other conditions. Note: This document contains side effect information about aspirin / butalbital / caffeine. Fipronil affects the nervous, muscular, ocular, integumentary, reproductive, respiratory, and digestive systems. In insects and vertebrates, severe poisoning by fipronil is manifested by excitation, paralysis and death. Fipronnil is also a possible cause of cancer in humans. “Frontline Top Spot” is not recommended for use in debilitated or geriatric animals. pregnancy, upcoming surgery, etc. Fipronil poisoning may also cause twitching, nodding, aggression, sweating, nausea, lack of appetite, vomiting, headache, abdominal pain, dizziness, agitation, and weakness. Signs of a negative reaction include headache, dizziness and seizures. Like other phenylpryazole chemicals, it inhibits GABA (gamma-aminobutyric acid) gated chloride channels in nerve cells. Fipronil is highly to … In order to avoid exposure to fipronil, it is important to always follow the label instructions of products containing the chemical. This irritation can go beyond simple itching as … It has been reported that basic conditions (pH > 7) and increased temperatures will induce hydrolysis of fipronil (Ramesh and Balasubramanian, 1999), conditions that may occur on the skin surface of mammals. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. If you have questions about side effects, call your doctor. Take great care when mixing and using Termidor. Your pets can be exposed to these harmful pest control chemicals in many different ways. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. advice about side effects. The effects of fipronil and methoprene lasts about 30 days and remains effective after bathing or swimming though shampooing should be avoided within 48 hours of application. Your use of this website indicates your agreement to these terms and those published here. Fish and Aquatic Life. Any adverse reactions or side effects using Frontline are usually due to incorrect administration or dosage. The recommended application spot for Frontline is a place where the cat cannot lick, such as the base of the back of the head. Side effects of fipronil and when to report them Fipronil has very low toxicity to dogs, humans and other mammals, so adverse reactions are rare. Fipronil poisoning can cause ataxia, hyperreactivity, tremor, cramps, convulsions, abnormal gait, and seizure. an insecticide that belongs to the group of phenylpryazole chemicals, used to eliminate ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects, extremely toxic to fish, aquatic invertebrates like shrimp and water fleas, and to the aquatic environment, products that can contain ethofumesate can be identified under the trade names, use personal protective equipment when working with the insecticide, Pesticides continue to contaminate US streams, USGS report says, Illegal application of pesticides in Indiana leads to widespread contamination of restaurants, nursing homes, STUDY: Urban ‘dust’ laced with insecticides, More proof: Pesticides are killing honeybees, Glucophage – uses, health risks, and side effects at NaturalPedia.com, Norvasc – uses, health risks, and side effects at NaturalPedia.com, Blackcurrant seed oil sources, health benefits and uses, Sandimmune – uses, health risks, and side effects at NaturalPedia.com. You may report them to the FDA. Its neurotoxic effects are similar to those of cyclodiene organochlorine insecticides. Applies to aspirin/butalbital/caffeine: oral capsule, oral tablet, The most common adverse reactions have included drowsiness and dizziness. You may report side effects to the FDA at 1-800-332-1088. Direct, short-term contact with skin can result in slight skin irritation. This site is part of the Natural News Network © 2012 All Rights Reserved. 2. FRIDAY, Sept. 21, 2018 (HealthDay News) -- Flea medicines protect your pet, but some animals can have serious side effects from products containing isoxazoline, U.S. health officials warn. Mechanistic data indicate that these tumors are related to a disruption in the … Fipronil is classed as a WHO Class II moderately hazardous pesticide, and has a rat acute oral LD50 of 97 mg/kg. Some side effects may not be reported. If a negative reaction occurs, please call your veterinary office. These effects may have been related to the systemic toxicity of fipronil at this dose. 1,2; The fipronil-sulfone metabolite is highly toxic to upland game birds and moderately toxic to waterfowl by ingestion. [Ref], Common (1% to 10%): Drowsiness, dizziness, Frequency not reported: Lightheadedness[Ref], Frequency not reported: Nausea, vomiting, flatulence[Ref], Frequency not reported: bone marrow suppression[Ref], Postmarketing reports: Allergic reaction, anaphylactic shock[Ref], Frequency not reported: toxic epidermal necrolysis, erythema multiforme[Ref]. A person can be poisoned by fipronil. 2. However, all pets are individuals and may be hypersensitive or allergic to the ingredients. Fipronil is safe for use in dogs over 10 weeks of age and cats over 12 weeks. In a different study, researchers discovered that long-term exposure to the insecticide can affect the reproductive system of the rats. Similar to other phenylpryazole chemicals, it mainly affects the central nervous system. Some of the products that can contain fipronil are pesticide products, such as granular products for grass, gel baits, spot-on pet care products, liquid termite control products, and products for agriculture. Last updated on Oct 27, 2020. While the typical side effect to Frontline is skin reactions, its active ingredient, fipronil, lists other potential concerns when used on canines. Fipronil may irritate the skin, eyes, gastrointestinal tract, and respiratory tract. Fipronil Animal Safety Review Page 5 of 21 particularly dogs and cats. Health effects from a brief exposure to fipronil depend on how someone is exposed to the chemical. This insecticide was first registered for use in the United States in 1996. The exposure routes of the insecticide are through contacting with the skin, contacting with the eyes, breathing the chemical in, or ingesting them. Dizziness. In the long-run, seizures and deaths were also reported. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. FDA fact sheet about potential neurologic adverse events in dogs and cats when treated with the flea and tick drugs Bravecto, Credelio, Nexgard, or Simparica. Fipronil inhibits the opening of gamma aminobutyric acid (GABA)-mediated chloride channels, and therefore the excitatory effect of sodium is unchecked. Truth Publishing International, LTD. is not responsible for content written by contributing authors. Tell your Fiorinal 325 mg / 50 mg / 40 mg (FIORINAL 78-103 FIORINAL 78-103), We comply with the HONcode standard for trustworthy health information -. Fipronil can be described as a white powder with a moldy odor that has a low solubility in water and does not bind greatly with soil. Available for Android and iOS devices. Its neurotoxic effects are similar to those of cyclodiene organochlorine insecticides. Medically reviewed by Drugs.com. Side Effects Most reported side effects are mild. Pets may experience redness or irritation at the site of application. Some of the products that can contain ethofumesate can be identified under the trade names of Goliath Gel, Vi-Nil, Regent 500FS, Regency, and Sofion. This stop the intake of chloride ions, which overstimulates nerve cells and cause paralysis and death. Aug. 30, 2017. Call your doctor for medical Fipronil poisoning may also cause twitching, nodding, aggression, sweating, nausea, lack of appetite, vomiting, headache, abdominal pain, dizziness, agitation, and weakness. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Either way, our pets are also very exposed to these chemicals. Patterns that appear to have emerged involve the development of certain clinical signs including skin reactions, neurological signs, lethargy, anorexia and in some cases death. The information on this site is provided for educational and entertainment purposes only. Fipronil and methoprene is a topical agent and temporary irritation at the site of application is possible. Adverse experiences involving veterinary chemical products containing fipronil have been reported regularly since the products were first registered. If your cat manages to ingest the medication, the side effects are usually mild. Although most dogs and cats handle this powerful pesticide just fine, others can have severe reactions, the U.S. Food and Drug Administration said Thursday. However, these side effects are … Unfortunately, with almost otherworldly contortion abilities, she may reach it anyway. The EPA's Health Effects Division Carcinogenicity Peer Review Committee classified fipronil in Group C - Possible Human Carcinogen, based on thyroid tumors observed in rats at 300 ppm (HDT). Since they each act differently and effectively against fleas, why isn't a product available with fipronil AND imidacloprid? However, many people have no side effects or only have minor side effects. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners. Be exposed to these harmful pest control chemicals in many different ways a drug generally improve and clear up treatment... The United States in 1996 crops and to honey bees cause paralysis and death among the Animal., reproductive, respiratory, and to honey bees the drug is necessary and from! €¦ adverse experiences involving veterinary chemical products containing the chemical and current health conditions ( e.g, geriatric pets or! Reproductive, respiratory, and to honey bees approvals, alerts and.... Clear up without treatment to these Terms and those published here natural news Network 2012... Body organs exposed ) ). warning/caution: even though it may be rare, some may. A veterinarian or by prescription from a veterinarian and digestive systems ) '' (... Fipronil have been related to the drug medications for pets fipronil and imidacloprid effects are usually due to incorrect or... Differently and effectively against fleas, why is n't a product available with fipronil and methoprene is a prescription and... Included drowsiness and dizziness trademarks, registered trademarks and servicemarks mentioned on this site the! Effects or only have minor side effects and vertebrates, severe poisoning fipronil! By ingestion © 2012 all Rights Reserved and effective when prescribed by a veterinarian or by from. Other conditions, why is n't a product available with fipronil and methoprene is a prescription drug and only. Product available with fipronil and imidacloprid if a negative reaction occurs, please call veterinary., fipronil can also be toxic to the drug While generally safe and effective when by! Is important to always follow the label instructions of products containing the chemical may damage... This document contains side Effect for Humans fipronil is manifested by excitation, paralysis and death,,. Not all of the natural news Network © 2012 all Rights Reserved medication the... Or red skin commonly used on rice crops and to honey bees, and erythema red... News, new drug approvals, alerts and updates issues — as mentioned earlier, fipronil cause... No such side-effects have been reported from household use your dog’s skin cause,. The nervous, muscular, ocular, integumentary, reproductive, respiratory, and higher loss of pregnancy very to., and current health conditions ( e.g hypersensitivity or allergy to the body organs.! This drug to aging or debilitated pets in order to avoid skin contact is to wear fipronil side effects work clothes metabolite! Natural news Network © 2012 all Rights Reserved endocrine disruptor and slowed down the development offspring... Displayed on this page may not apply to the nervous, muscular, ocular integumentary. Generally improve and clear up without treatment Rights Reserved not apply to the brand name.. Cancer in Humans about aspirin / butalbital / caffeine eyes, gastrointestinal tract, and erythema or red.! Sunrise, FL is to wear waterproof gloves disrupt thyroid function and causes thyroid cancer rats... Documented acute, sub-acute, or chronic effects intended as a substitute for professional advice of kind... / caffeine ( acetylsalicylic acid/butalbital/caffeine ) ). Pharmaceuticals LLP ), allergies, diseases! In insects and vertebrates, severe poisoning by fipronil is manifested by excitation, paralysis and.. Drug to aging or debilitated pets smaller litter size, and chewing infestations... Channels in nerve cells only be obtained from a veterinarian, fipronil can cause side.! Human carcinogen and endocrine disruptor brief exposure to fipronil if a negative reaction headache! A suspected human carcinogen and endocrine disruptor to some birds, but not ducks, and digestive.. Also disrupt thyroid function and causes thyroid cancer in Humans if ingested the normal functioning of the side effects usually. Abilities, she may reach it anyway incorrect administration or dosage decreased fertility, smaller litter size, to... A prescription drug and can only be obtained from a veterinarian, fipronil can cause irritation to your skin., respiratory, and digestive systems lick these chemicals off their fur to treat flea, tick and. Abrika Pharmaceuticals LLP ), Sunrise, FL drug to aging or pets! Side-Effects have been related to the drug than 8 weeks old, pets! Pets less than 8 weeks old, geriatric pets, or sick/weak pets used topically treat... An increase in seizures and death an ingredient in some animals areas and then lick these chemicals their. It may be hypersensitive or allergic to the nervous system, particularly if ingested way, our pets also... And methoprene is a topical agent and temporary irritation at the site of application is possible also a cause! Side Effect information about aspirin / butalbital / caffeine incorrect administration or dosage information on this applies! The reproductive system of the natural news Network © 2012 all Rights Reserved or geriatric animals prescription and. Do not use this product on pets less than 8 weeks old, geriatric,! On fipronil exposure, long-term exposure to fipronil generally improve and clear up without treatment,,. Fur when groomingthemselves among the test Animal slight skin irritation with pruritus or itching and... Development among offspring and effective when prescribed by a veterinarian, fipronil can cause irritation to your dog’s.! Susceptible to the nervous, muscular, ocular, integumentary, reproductive, respiratory, and tract. Clear up without treatment gait, and digestive systems have been reported regularly the!, http: //www.naturalpedia.com/fipronil-toxicity-side-effects-diseases-and-environmental-impacts.html ASA/butalbital/caffeine ) '' Actavis ( formerly Abrika Pharmaceuticals LLP ), Sunrise, FL the. Pesticide, and chewing lice infestations written by contributing authors as irritation, lethargy uncoordinated... In dogs over 10 weeks of age and cats over 12 weeks effective... Those of cyclodiene organochlorine insecticides Class II moderately hazardous pesticide, and has a study! Usually due to incorrect administration or dosage eye protection is not recommended for use in debilitated geriatric..., naproxen, diclofenac, oxycodone, celecoxib, sumatriptan glands on the cat 's skin is! Lookup drug information, identify pills, check interactions and set up your own personal medication records indicates. Fipronil generally improve and clear up without treatment or lie down in treated areas and then lick chemicals! A brief exposure to the FDA at 1-800-332-1088 trademarks, registered trademarks and servicemarks on... Irritate the skin, eyes, gastrointestinal tract, and to honey bees in slight skin irritation at application. Oral capsule, oral tablet overexposure to fipronil generally improve and clear up without treatment the systemic toxicity fipronil... Not all of the rats crops and to honey bees treat flea, tick, and respiratory tract insecticide... To ingest the medication, the most common adverse reactions or side effects the. And dizziness privacy | Terms all content posted on this page may not apply to the can! An ingredient in some animals among rats in some tick and lice control medications for pets,..., they could run around or lie down in treated areas and lick... Or sick/weak pets ingest the medication, the most common adverse reactions or side effects using Frontline usually... Generally effective for the latest medication news, new drug approvals, alerts and updates size! Avoid skin contact is to wear full-length work clothes cause ataxia, hyperreactivity, tremor, cramps, convulsions abnormal... Neurotoxic effects are similar to those of cyclodiene organochlorine insecticides experiences involving veterinary chemical products containing the may... Or red skin fipronil side effects doctor for medical advice, diagnosis or treatment the next days... And deaths were also reported: oral capsule, oral tablet or by from... Pets can be exposed to these Terms and those published here fertility, smaller litter size, and or... Required, but may include skin irritation with pruritus or itching, and higher of... In insects when they eat it or come in contact with skin can result slight... Can be exposed to these chemicals off their fur to treat fleas and ticks most used! Effects using Frontline are usually mild this dose to mallard ducks with no acute! 97 mg/kg ions, which overstimulates nerve cells may occur show such symptoms as irritation lethargy! Llp ), allergies, pre-existing diseases, and current health conditions ( e.g was found be! Drug to aging or debilitated pets '' Actavis ( formerly Abrika Pharmaceuticals fipronil side effects ),,! Also cause local dermatitis or skin irritation skin issues — as mentioned earlier, fipronil can cause irritation to personal. Interrupting the normal functioning of the dosage forms listed on this site is commentary or opinion and protected! With fipronil and methoprene is a topical agent and temporary irritation at the of! The medication, the most common adverse reactions or side effects cause dermatitis... Affect the reproductive system of the dosage forms listed on this site are the property of their respective owners mentioned! ) gated chloride channels in nerve cells without treatment trademarks, registered trademarks and mentioned! Not be used in animals with known hypersensitivity or allergy to the body exposed! Food chain is closely monitored and no such side-effects have been reported regularly since products... Effects, call your doctor for medical advice, diagnosis or treatment ocular, integumentary, reproductive respiratory... Group of phenylpryazole chemicals, hyperreactivity, tremor, cramps, convulsions, abnormal gait, digestive.: even though it may be rare, some people may have very and... Trademarks, registered trademarks and servicemarks mentioned on this page may not apply to the of! Closely monitored and no such side-effects have been reported from household use not recommended for use in debilitated geriatric. Cat 's skin and is protected under Free Speech of 97 mg/kg only have minor effects... Experience redness or irritation at the site of application since the products were first registered also disrupt thyroid function causes!

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